Mekanisme molekuler ketergantungan terhadap nikotin
Abstract
Nicotine, the main addictive substance of tobacco, plays an important role in the dependence mechanism. Complex interactions between the central and peripheral nervous systems lead to nicotine dependence, primarily due to activation of nicotinic acetylcholine receptors in the brain. Activation of these receptors triggers the release of neurotransmitters, such as dopamine, that make people feel euphoric and calm, which encourages repeated nicotine use behavior. In addition, dopaminergic and glutamatergic signaling pathways undergo molecular changes, resulting in neuroplastic changes and increased tolerance to nicotine. This study focuses on the role of nicotinic acetylcholine receptors, neurotransmitter regulation, and neuroplastic changes in the limbic system. Understanding these mechanisms can help develop better therapeutic methods to overcome nicotine dependence and reduce the adverse effects caused by nicotine consumption.
Downloads
References
Asrofik, Rahmawati, I., Rozak, A. K., & Amiruddin, M. (2024). Kebudayaan Kesehatan Islam: Tinjauan Sejarah dan Relevansinya dalam Kesehatan Masyarakat Kontemporer. Ameena Journal, 2(3), 280–297. https://doi.org/10.63732/aij.v2i3.107
Astiti, I. N., Anggraito, Y. U., & Syaifudin, M. (2018). Analisis Tingkat Kerusakan DNA pada Sel Limfosit Perokok dan Non Perokok Akibat Paparan Radiasi Gamma dengan Teknik Comet Assay. Life Science, 7(1), 16–23.
Elon, Y., & Malinti, E. (2019). Fenomena merokok pada anak usia remaja: Studi kualitatif. Klabat Journal of Nursing, 1(1), 78–87.
Fauziyah, N. (2022). Eksplorasi nilai-nilai sosial budaya pada remaja millenial. WASKITA: Jurnal Pendidikan Nilai Dan Pembangunan Karakter, 6(2), 218–232. http://repository.uin-malang.ac.id/10933/
Nasution, I. K. (2007). Perilaku merokok pada remaja.
Wijaya, D., Annisa, R., & Anggraini, W. (2021). Pendekatan kesehatan masyarakat dalam penerapan adaptasi kebiasaan baru. N: The Covidpedia. Media Nusa Creative, Malang, pp. 1-20. ISBN 978-602-462-588-7. http://repository.uin-malang.ac.id/9770/
Copyright (c) 2025 nur. silmi.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
