Pengaruh Skincare Berbasis Nanoemulsi terhadap Penyerapan Zat Aktif di Kulit
Abstract
The advancement of nanotechnology in skincare formulation offers new opportunities to enhance the delivery of active ingredients into the skin. Nanoemulsions with droplet sizes ranging from 20 to 200 nm, improve solubility, stability, and penetration of active compounds through the stratum corneum, which is the main barrier to topical absorption. This literature review aims to analyze the effect of nanoemulsion-based skincare on the absorption of active ingredients into the skin based on national and international studies. The findings indicate that research in Indonesia has successfully formulated nanoemulsions with particle sizes below 200 nm, showing good stability and biological activities such as antioxidant, anti-aging, and hair growth stimulation. However, most local studies remain limited to physical characterization without direct skin penetration tests. In contrast, international studies have more frequently incorporated both in vitro and in vivo evaluations to measure penetration and bioavailability. Therefore, nanoemulsions hold great potential as a delivery system for active compounds in skincare, but further research is needed to assess actual skin penetration and long-term safety.
Downloads
References
Alvarez-Rom#x00E1;n, R., Naik, A., Kalia, Y. N., Guy, R. H., & Fessi, H. (2004). Enhancement of Topical Delivery from Biodegradable Nanoparticles. Pharmaceutical Research, 21(10), 1818–1825. https://doi.org/10.1023/B:PHAM.0000045235.86197.ef
Chen, K., Yang, H., Xu, G., Hu, Y., Tian, X., Qin, S., & Jiang, T. (2025). Enhanced skin penetration of curcumin by a nanoemulsion-embedded oligopeptide hydrogel for psoriasis topical therapy. RSC Medicinal Chemistry, 16, 961–969. https://doi.org/10.1039/D4MD00781F
Handayani, L., dkk. (2021). Pengembangan formula dan karakterisasi nanoemulsi ekstrak kombinasi daun teh dan mangkokan. Pharmascience (Journal of Pharmacy and Science), 8(2), 115–124.
Hutabarat, A., dkk. (2023). Formulasi dan Evaluasi Nanoemulsi Gel Vitamin E (α-Tokoferol). Talenta Conference Series: Tropical Medicine and Pharmacy, 6(2), 270–278.
Labouta, H. I., & Schneider, M. (2013). Interaction of inorganic nanoparticles with the skin barrier: Current status and critical review. Nanomedicine: Nanotechnology, Biology and Medicine, 9(1), 39–54. https://doi.org/10.1016/j.nano.2012.04.004
Lestari, I., dkk. (2022). Formulasi dan Evaluasi Sediaan Nanoemulsi Ekstrak Umbi Bawang Putih (Allium sativum L.). Jurnal Sains dan Kesehatan (JSK), 4(5), 602–610.
Madison, K. C. (2003). Barrier function of the skin: “La raison d’être” of the epidermis. Journal of Investigative Dermatology, 121(2), 231–241. https://doi.org/10.1046/j.1523-1747.2003.12359.x
Menon, G. K., Cleary, G. W., & Lane, M. E. (2012). The structure and function of the stratum corneum. International Journal of Pharmaceutics, 435(1), 3–9. https://doi.org/10.1016/j.ijpharm.2012.06.005
Pratiwi, R., dkk. (2021). Formulasi dan Uji Sifat Fisik Sediaan Nanoemulsi Natrium Diklofenak. Jurnal SAINTEKS, 8(1), 45–53.
Rahmawati, N., dkk. (2022). Formulasi Nanoemulsi Gel Ekstrak Bunga Telang (Clitoria ternatea) sebagai Antioksidan. Safana: Journal of Pharmacy and Health, 3(2), 120–129.
Shakeel, F., Shafiq, S., Haq, N., Alanazi, F. K., Alsarra, I. A., & Kharshid, A. (2012). Nanoemulsions as vehicles for transdermal delivery of aceclofenac. Journal of Molecular Liquids, 165, 168–172. https://doi.org/10.1016/j.molliq.2011.11.006
Solans, C., Izquierdo, P., Nolla, J., Azemar, N., & Garcia-Celma, M. J. (2005). Nano-emulsions. Current Opinion in Colloid & Interface Science, 10(3–4), 102–110. https://doi.org/10.1016/j.cocis.2005.06.004
Souto, E. B., Cano, A., Martins-Gomes, C., Coutinho, T. E., Zielińska, A., & Silva, A. M. (2022). Microemulsions and Nanoemulsions in Skin Drug Delivery. Bioengineering, 9(4), 158. https://doi.org/10.3390/bioengineering9040158
Copyright (c) 2025 Sabita Lutfun Nisa Ramdhini Parvez
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
